Hepatitis B vaccines
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چکیده
In accordance with its mandate to provide guidance to Member States on health policy matters, WHO is issuing a series of regularly updated position papers on vaccines and vaccine combinations against diseases that have an international public health impact. These papers are concerned primarily with the use of vaccines in large-scale immunization programmes; limited vaccination, as executed mostly in the private sector, may be a valuable supplement to national programmes but is not emphasized in these policy documents. The position papers summarize essential background information on the respective diseases and vaccines and conclude with the current WHO position concerning vaccine use in the global context. The papers have been reviewed by a number of experts within and outside WHO and are designed for use mainly by national public health officials and immunization programme managers. However, the position papers may also be of interest to international funding agencies, the vaccine manufacturing industry, the medical community and the scientific media.
منابع مشابه
Current progress in the development of therapeutic vaccines for chronic hepatitis B virus infection
Chronic hepatitis B is still a major public health issue despite the successful prophylactic vaccination attempts. Chronicity of hepatitis B virus(HBV) is mainly due to its ability to debilitate host's immune system. Therefore, major measures have been taken to stop this process and help patients with chronic hepatitis B infection recover from their illness. While satisfactory results have been...
متن کاملSTUDIES ON HEPATITIS B VACCINES
HBs vaccines were prepared by three different methods: 1) Heat inactivation (Krugman, et.al 1971)2) Ammonium sulphate precipitation followed by column chromatography (Sephadex G-200) 3) PEG-6000 (polyethylene glycol) precipitation followed by column chromatography using Sephadex G-200. Their efficacy was studied in guinea pigs, and the results compared with commercial Japanese vaccine (Gr...
متن کاملEvaluation of Thimerosal Removal on Immunogenicity of Aluminum Salts Adjuvanted Recombinant Hepatitis B Vaccine
Thimerosal, which is approximately 50% mercury by weight is a preservative widely used in vaccines since the 1930’s. It meets the requirements for a preservative as set forth by Pharmacopeia challenge test and has been shown to be effective against a broad spectrum of pathogens. In July 1999, the Public Health Service agencies and vaccine manufacturers agreed that thimerosal should be redu...
متن کاملEvaluation of Thimerosal Removal on Immunogenicity of Aluminum Salts Adjuvanted Recombinant Hepatitis B Vaccine
Thimerosal, which is approximately 50% mercury by weight is a preservative widely used in vaccines since the 1930’s. It meets the requirements for a preservative as set forth by Pharmacopeia challenge test and has been shown to be effective against a broad spectrum of pathogens. In July 1999, the Public Health Service agencies and vaccine manufacturers agreed that thimerosal should be redu...
متن کاملEpidemiological studies of hepatitis B: Preliminary report on adjuvant potential of Calotropis gigantea and Ficus religiosa against hepatitis B vaccine containing surface antigen
Background and aims: The frequency of chronic hepatitis B virus infection varies totally in different part of the world but it could be categorized as high, intermediate and low endimicity. In this regard, development of safe and effective vaccines against infectious diseases especially hepatitis B virus that are still required for emerging new pathogens, re-emerging old pathog...
متن کاملComparison of the Adjuvanticity of Aluminum Salts and Their Combination in Hepatitis B Recombinant Protein Vaccine Assessed in Mice
Background: Several adjuvants have been evaluated for vaccine formulations but alu-minum salts will continue to be used for many years due to their safety, low cost and adjuvanticity with different antigens. Two commonly used aluminum adjuvants, alumi-num hydroxide and aluminum phosphate have different adjuvanticity properties. Com-mercial recombinant protein hepatitis B vaccines containing alu...
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